Opioid Research

Volume 84 of the series Methods in Molecular Biology™ pp 157-183

Opioid Receptor Oligomerization

Detection and Functional Characterization of Interacting Receptors
  • Ivone GomesAffiliated withDepartment of Pharmacology and Biological Chemistry
  • , Lakshmi A. DeviAffiliated withDepartment of Pharmacology and Biological Chemistry
  • , Julija FilipovskaAffiliated withDepartment of Biochemistry and Molecular Biology, University of Barcelona

* Final gross prices may vary according to local VAT.

Get Access


Opioid receptors are members of the G-protein coupled receptor (GPCR) family characterized by the presence of seven transmembrane domains. These receptors are classified as mu (μ), delta (δ), and kappa (κ). Activation of these receptors leads to uncoupling of the inhibitory G-proteins (Gi) followed by the activation of multiple signal transduction pathways including the inhibition of adenylyl cyclase, modulation of inwardly rectifying K+ channels or voltage-dependent calcium channels and regulation of mitogen-activated protein (MAP) kinase activity (14).