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Protein Structure Prediction

Volume 143 of the series Methods in Molecular Biology™ pp 131-154

A Practical Guide to Protein Structure Prediction

  • David T. JonesAffiliated withDepartment of Biological Sciences, University of Warwick

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Abstract

The protein-folding problem is one of the greatest remaining challenges in structural molecular biology (if not the whole of biology). How do proteins translate from their primary structure (sequence) to tertiary structure? How is the information encoded? Basically, how do proteins fold? Often, the protein-folding problem is seen as a computational problem—do we know enough about the rules of protein structure to program a computer to read in a protein sequence and output a correct tertiary structure? Aside from the academic interest in understanding the physics and chemistry of protein folding, why are so many people interested in finding an algorithm (i.e., a method) for predicting the native structure of a protein given just its sequence?