Protocol

Hepatitis C Protocols

Volume 19 of the series Methods in Molecular Medicine™ pp 183-198

HCV Genotyping by the Line Probe Assay INNO-LiPA HCV II

  • Geert MaertensAffiliated withHepatitis Program, Innogenetics
  • , Lieven StuyverAffiliated withHepatitis Program, Innogenetics

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Abstract

Hepatitis C viruses (HCVs) constitute a highly variable genus within the Flaviviridae, with closest homology to the hepatitis G and GB viruses, and Pestiviruses. The positive-stranded RNA genome encodes a polyprotein which is co- and posttranslationally cleaved into at least nine proteins. Core, E1, and E2 (the structural proteins) and NS2, NS3, NS4A, NS4B, NS5A, and NS5B (the nonstructural [NS] proteins). A theoretical protein of 7 kDa (tp7) may be processed from the carboxy terminal E2 region (1).