Summary
A new therapeutic trial aimed at assisting tissue regeneration at a body defect in size too large for self-repair has recently begun. The objective is to substitute the biological functions of damaged and injured organs by taking advantage of cells. For successful tissue regeneration, it is absolutely indispensable not only to have cells of high proliferation and differentiation potential, but also to create an environment suitable for inducing regeneration. Such creation can be artificially achieved only by providing various biomaterials to promote cell proliferation and differentiation, such as cell scaffold and growth factors. Growth factors are often required to promote tissue regeneration because they can induce angiogenesis, which promotes a sufficient supply of oxygen and nutrients to effectively maintain the biological functions of cells transplanted for organ substitution. However, because of their poor in vivo stability, the biological effects of growth factors cannot always be expected unless these drug delivery systems (DDSs) are contrived. In this chapter, several research approaches to tissue regeneration are reviewed to emphasize the significance of biomaterials and DDS technologies in regenerative medicine.
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Tabata, Y. (2001) Significance of biomaterials and drug delivery systems in tissue engineering. Connect. Tissue 33, 315–324.
Prokop, A., Hunkeler, D., and Cherrington, A. D. (1997) Bioartificial organs, sciences, medicine, and technologies. Ann. NY Acad. Sci. USA 831, 249–298.
Humes, H. D., Buffington, D. A., MacKay, S, M., Funke, A. J., and Weitzel, W. F. (1999) Replacement of renal function in uremic animals with a tissue-engineered kidney. Nat. Biotechnol. 17, 451–455.
Tsubota, K., Satake, Y., Kaido, M., Shinozaki, M., Shimmura, S., Bissen-Miyajima, H., and Shimazaki, J. (1999) Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N. Engl. J. Med. 340, 1697–1703.
Li, R. K., Jia, Z.-Q., Weisel, R. D., Mickle, D. A., Zhang, J., Mohabeer, M. K., Rao, V., and Ivanov, J. Cardiomyocyte transplantation improves heart function. (1996) Ann. Thorac. Surg. 62, 654–660.
Shimizu, Y. (1998) Tissue engineering for soft tissue, in The Tissue Engineering for Therapeutic Use 2 (Ikada, Y. and Enomoto, S., eds.), Elsevier Science B.V. Publisher, Amsterdam, The Netherlands, pp. 119–122.
Yannas, I. V. and Burke, J. F. (1980) Design of an artificial skin. 1. Basic design principle. J. Biomed. Mater. Res. 14, 65–81.
Okumura, N., Nakamura, T., Shimizu, Y., Tomihata, K., Ikada, Y., and Shimizu, Y. (1994) Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh. J. Thorac. Cardiovasc. Surg. 108, 337–341.
Takimoto, Y., Nakamura, T., Yamamoto, Y., Kiyotani, T., Teramachi, M., and Shimizu, Y. (1998) The experimental replacement of a central esophageal segment with an artificial prosthesis with the use of collagen matrix and a silicone stent. J. Thorac. Cardiovasc. Surg. 116, 98–106.
Yamada, K., Miyamoto, S., Nagata, I., Kikuchi, H., Ikada, Y., Iwata, H., and Yamamoto, K. (1997) Development of a dural substitute from synthetic bioabsorbable polymers. J. Neurosurg. 86, 1012–1017.
Shinoka, T., Shum-Tim, D., Ma, P. X., Tanel, R. E., Isogai, N., Langer, R., Vacanti, J. P., and Mayer, J. E. Jr. (1998) Creation of viable pulmonary artery autografts through tissue engineering. J. Thorac. Cardiovasc. Surg. 115, 536–546.
Kaihara, S., Kim, S. S., Kim, B. S., Mooney, D., Tanaka, K., and Vacanti, J. P. (2000) Long-term follow-up of tissue-engineered intestine after anastomosis to native small bowel. Transplantation 69, 1927–1932.
Ohgushi, H. and Caplan, A. I. (1999) Stem cell technology and bioceramics: from cell to gene engineering. J. Biomed. Mater. Res. (Appl. Biomater.) 48, 913–927.
Pittenger, M. F., Mackay, A. M., Beck, S. C. Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., and Marshak, D. R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143–147.
Isogai, N., Landis, W., Kim, T. H., Gerstenfeld, L. C., Upton, J., and Vacanti, J. P. (1999) Formation of phalanges and small joints by tissue-engineering. J. Bone Joint Surg. 81, 306–316.
Valentini, R. F. (1995) Nerve guidance channels, in The Biomedical Engineering Handbook (Brozine, J. D., ed.), CRC Press, Boca Raton, FL, pp. 1985–1996.
Ishikawa, I. and Arakawa, S. (1998) Awareness of periodontal disease—the role of industry. Intern. Dent. J. 48, 261–267.
Parker, C. W. (1990) Radiolabelling of proteins. Methods Enzymol. 182, 721–737.
Bonadio, J., Goldstein, S. A., and Lecy, R. J. (1998) Gene therapy for tissue repairing and regeneration. Adv. Drug Deliv. Rev. 33, 53–69.
Lee, J. S. and Feldman, A. M. (1998) Gene therapy for therapeutic myocardial andiogenesis: a promising synthesis of two emerging technologies. Nat. Med. 4, 739–742.
Bonadio, J., Smiley, E., Patil, P., and Goldstein, S. (1999) Localized, directed plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue engineering. Nat. Med. 5, 753–759.
Tabata, Y. and Ikada, Y. (1998) Protein release from gelatin matrices. Adv. Drug Deliv. Rev. 31, 287–301.
Tabata, Y., Nagano, A., and Ikada, Y. (1999) Biodegradation of hydrogel carrier incorporating fibroblast growth factor. Tissue Eng. 5, 127–138.
Tabata, Y., Hijikata, S., Munirzzaman, M. D., and Ikada, Y. (1999) Neovascularization through biodegradable gelatin microspheres incorporating basic fibroblast growth factor. J. Biomater. Sci. Polym. Ed. 10, 79–94.
Tabata, Y., Morimoto, K., Katsumata, H., Yabuta, T., Iwanaga, K., Kakemi, M., and Ikada, Y. (1999) Surfactant-free preparation of biodegradable hydrogel microspheres for protein release. J. Bioactive Compatible Polym. 14, 371–384.
Rifkin, D. B. and Moscatelli, D. (1989) Structural characterization and biological functions of basic fibroblast growth factor. J. Cell Biol. 109, 1–6.
Tabata, Y. and Ikada, Y. (1999) Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 20, 2169–2175.
Wang, W., Gu, Y., Tabata, Y., Miyamoto, M., Hori, H., Nagata, N., Touma, M., Balamurugan, A. N., Kawakami, Y., Nozawa, M., and Inoue, K. (2002) Reversal of diabetes in mice by xenotransplantation of a bioartificial pancreas in a prevascularized subcutaneous site. Transplantation 73, 122–129.
Ogawa, K., Asonuma, K., Inamoto, Y., Tabata, Y., and Tanaka, K. (2001) The efficacy of prevascularization by basic FGF for hepatocyte transplantation using polymer devices in rats. Cell Transplant. 83, 281–302.
Sakakibara, Y., Nishimura, K., Tambara, K., Yamamoto, M., Lu, F., Tabata, Y., and Komeda, M. (2002) Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation. J. Thorac. Cardiovasc. Surg. 124, 50–56.
Tabata, Y., Yamada, K., Miyamoto, S., Nagata, I., Kikuchi, H., Aoyama, I., Tamura, M., and Ikada, Y. (1998) Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogel. Biomaterials 19, 807–815.
Tabata, Y., Yamada, K., Hong, L., Miyamoto, S., Hashimoto, N., and Ikada, Y. (1999) Skull bone regeneration in primates in response to basic fibroblast growth factor. J. Neurosurg. 91, 851–856.
Hong, L., Tabata, Y., Yamamoto, M., Miyamoto, S., Yamada, K., Hashimoto, N., and Ikada, Y. (1998) Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution. J. Biomater. Sci. Polym. Ed. 9, 1001–1014.
Hong, L., Tabata, Y., Miyamoto, S., Yamamoto, M., Yamada, K., Hashimoto, N., and Ikada, Y. (2000) Bone regeneration at rabbit skull defects treated with transforming growth factor-β1 incorporated into hydrogels with different levels of biodegradability. J. Neurosurgery 92, 315–325.
Yamamoto, M., Tabata, Y., Hong, L., Miyamoto, S., Hashimoto, N., and Ikada, Y. (2000) Bone regeneration by transforming growth factor β1 released from a biodegradable hydrogel. J. Control. Release 64, 133–142.
Hong, L., Tabata, Y., Miyamoto, S., Yamada, K., Aoyama, I., Tamura, M., Hashimoto, N., and Ikada, Y. (2000) Promoted bone healing at rabbit skull gap between autologous bone fragment and the surrounding intact bone with biodegradable microspheres containing transforming growth factor β1. Tissue Eng. 6, 331–340.
Tabata, Y., Hong, L., Miyamoto, S., Miyao, M., Hashimoto, N., and Ikada, Y. (2000) Bone formation at a rabbit skull defect by autologous bone marrow combined with gelatin microspheres containing TGF-β1. J. Biomater. Sci. Polym. Ed. 11, 891–901.
Tabata, Y., Miyao, M., Inamoto, T., Ishii, T., Hirano, Y., Yamaoki, Y., and Ikada, Y. (2000) De novo formation of adipose tissue by controlled release of basic fibroblast growth factor. Tissue Eng. 6, 279–289.
Kimura, Y., Ozeki, M., Inamoto, T., and Tabata, Y. (2003) Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor. Biomaterials 24, 2513–2521.
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© 2005 Humana Press Inc., Totowa, NJ
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Tabata, Y. (2005). Nanomaterials of Drug Delivery Systems for Tissue Regeneration. In: Vo-Dinh, T. (eds) Protein Nanotechnology. Methods in Molecular Biology™, vol 300. Humana Press. https://doi.org/10.1385/1-59259-858-7:081
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DOI: https://doi.org/10.1385/1-59259-858-7:081
Publisher Name: Humana Press
Print ISBN: 978-1-58829-310-7
Online ISBN: 978-1-59259-858-8
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