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DNA Vaccines pp 221–239Cite as

Cytokine Fusion Constructs as DNA Vaccines Against Tumors

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 29))

Abstract

Various studies have used DNA vaccination as a method of immunizing against tumors (1–12). As with any tumor vaccine, one challenge is to find a truly tumor-specific antigen (13,14). The majority of immunologically targeted tumor antigens are also expressed on a subset of normal host cells. Examples of such antigens include prostate-specific antigen, and CD20, a B cell marker. Some tumor antigens are specific for activated cells of certain types, such as carcinoembryonic antigen (CEA) or the IL-2 receptor. These are often found on embryonic or fetal cells as well as tumor cells. The carbohydrate antigens of melanomas and the immunoglobulin (Ig) idiotype of B cell lymphomas represent tumor-specific antigens (TSA). Unfortunately, TSA have not been identified in more common malignancies. Furthermore, the antigenic determinants of known TSA may differ between patients; for example, the tumor idiotype (Id) of B cell lymphoma is highly patient-specific and must be determined for each case.

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Author information

Authors and Affiliations

  1. Department of Medicine/Oncology, Stanford University Medical Center, Stanford, CA

    Holden T. Maecker & Athanasia Syrengelas

  2. Division of Oncology, Stanford University School of Medicine, Stanford, CA

    Ronald Levy

Authors
  1. Holden T. Maecker
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  2. Athanasia Syrengelas
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  3. Ronald Levy
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Editor information

Editors and Affiliations

  1. Mycobacterial Research Laboratory, London, UK

    Douglas B. Lowrie MD

  2. Maxygen Inc., Redwood City, CA

    Robert G. Whalen MD

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© 2000 Humana Press Inc., Totowa, NJ

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Maecker, H.T., Syrengelas, A., Levy, R. (2000). Cytokine Fusion Constructs as DNA Vaccines Against Tumors. In: Lowrie, D.B., Whalen, R.G. (eds) DNA Vaccines. Methods in Molecular Medicine™, vol 29. Humana Press. https://doi.org/10.1385/1-59259-688-6:221

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  • DOI: https://doi.org/10.1385/1-59259-688-6:221

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-580-5

  • Online ISBN: 978-1-59259-688-1

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