Abstract
The most common procedure that has been developed for use in rats and mice to model fracture healing is described. The nature of the regenerative processes that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented, and general considerations when setting up an experiment using this model are described.
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Acknowledgments
This work is supported by NIH Grants AR056637 and AR062642.
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De Giacomo, A., Morgan, E.F., Gerstenfeld, L.C. (2014). Generation of Closed Transverse Fractures in Small Animals. In: Hilton, M. (eds) Skeletal Development and Repair. Methods in Molecular Biology, vol 1130. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-989-5_3
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DOI: https://doi.org/10.1007/978-1-62703-989-5_3
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-988-8
Online ISBN: 978-1-62703-989-5
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