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Gene Function Analysis

Volume 1101 of the series Methods in Molecular Biology pp 113-134

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Statistical Tools and R Software for Cancer Driver Probabilities

  • Giovanni ParmigianiAffiliated withDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute
  • , Simina BocaAffiliated withBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
  • , Jie DingAffiliated withDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute
  • , Lorenzo TrippaAffiliated withDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute

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Abstract

This chapter provides a description and illustration of CancerMutationAnalysis and Cancer MutationMCMC, two open source R packages specifically designed for the analysis of somatic mutations in cancer genome studies, at both the gene and gene-set levels.

Key words

Markov Chain Monte Carlo Gene mutation Cancer driver gene