Date: 21 Aug 2013

Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides

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An innovative macrocyclization approach via high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles leads to the desired cyclic products in high purities and good yields.