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Cellular and Subcellular Nanotechnology pp 93–98Cite as

Lipophilic-Formulated Gold Porphyrin Nanoparticles for Chemotherapy

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 991))

Abstract

Lipophilic formulation is an invaluable technique for the delivery of cancer drugs. Incorporation of poorly soluble and toxic compounds into a lipophilic carrier vehicle improves both the stability and compatibility in blood and body fluids. Currently, although a large proportion of novel cancer drugs are poorly water soluble, most existing drug carriers are only able to encapsulate hydrophilic drugs. As the ultimate goal of drug delivery (in particular cancer drug delivery) is to achieve high therapeutic effect with minimal toxicity, it would thus be beneficial to invest substantial efforts in the development of lipophilic carrier systems. Here we describe our technique to synthesize a lipophilic carrier for hydrophobic and toxic potent cancer drugs, such as gold(III) porphyrin.

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Author information

Authors and Affiliations

  1. Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China

    Puiyan Lee & Kenneth K. Y. Wong

Authors
  1. Puiyan Lee
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  2. Kenneth K. Y. Wong
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Editor information

Editors and Affiliations

  1. College of Pharmacy, Dept. Pharmaceutical Sciences, Midwestern University, N. 59th Avenue 19555, Glendale, 85308, Arizona, USA

    Volkmar Weissig

  2. , Department of Pharmaceutical Sciences, Midwestern University College of Pharmac, N. 59th Avenue 19555, Glendale, 85308, Arizona, USA

    Tamer Elbayoumi

  3. , Department of Pharmaceutical Sciences, Midwestern University College of Pharmac, N. 59th Avenue 19555, Glendale, 85308, Arizona, USA

    Mark Olsen

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Lee, P., Wong, K.K.Y. (2013). Lipophilic-Formulated Gold Porphyrin Nanoparticles for Chemotherapy. In: Weissig, V., Elbayoumi, T., Olsen, M. (eds) Cellular and Subcellular Nanotechnology. Methods in Molecular Biology, vol 991. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-336-7_10

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  • DOI: https://doi.org/10.1007/978-1-62703-336-7_10

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-335-0

  • Online ISBN: 978-1-62703-336-7

  • eBook Packages: Springer Protocols

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