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TRP Channels in Drug Discovery pp 141–151Cite as

Investigation of the Possible Role of TRP Channels in Schizophrenia

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Schizophrenia is a debilitating psychiatric disorder. The limitations of current treatments for schizophrenia have led to an ongoing search for new drug targets. The observations that subjects with schizophrenia have impaired thermoregulation, are less sensitive to pain than normal subjects, and exhibit reduced niacin flare responses suggested that TRPV1 channels, and possibly also other temperature-sensitive TRPs that are co-expressed with TRPV1 on sensory neurons, might be linked with schizophrenia. In order to model deficit in function of TRP channels in animals, capsaicin treatment of neonatal rats was used to induce lifelong loss of a high proportion of primary afferent neurons that co-express TRPV1 and related TRP channels. The methods used to test the proposal that TRPV1 deficit induces brain and behavioral changes expected in an animal model of schizophrenia are described.

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Author information

Authors and Affiliations

  1. School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia

    Loris A. Chahl

  2. Schizophrenia Research Institute, Sydney, NSW, Australia

    Loris A. Chahl

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  1. Loris A. Chahl
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Correspondence to Loris A. Chahl .

Editor information

Editors and Affiliations

  1. Transfusion Services, Monmouth Medical Center, Long Branch, New Jersey, USA

    Arpad Szallasi

  2. Department of Physiology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    Tamás Bíró

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Chahl, L.A. (2012). Investigation of the Possible Role of TRP Channels in Schizophrenia. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-095-3_8

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  • DOI: https://doi.org/10.1007/978-1-62703-095-3_8

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-094-6

  • Online ISBN: 978-1-62703-095-3

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