Skip to main content
SpringerLink
Log in
Book cover

Psychoneuroimmunology pp 105–120Cite as

Translational Implications of Inflammatory Biomarkers and Cytokine Networks in Psychoneuroimmunology

  • Protocol
  • First Online:

Part of the book series: Methods in Molecular Biology ((MIMB,volume 934))

Abstract

Developments in psychoneuroimmunology (PNI) need to be translated into personalized medicine to achieve better clinical outcomes. One of the most critical steps in this translational process is to identify systemic biomarkers for better diagnosis and treatment. Applications of systems biology approaches in PNI would enable the insights into the correlations among various systems and different levels for the identification of the basic elements of the psychophysiological framework. Among the potential PNI biomarkers, inflammatory markers deserve special attention as they play a pivotal role linking various health conditions and disorders. The elucidation of inflammatory markers, cytokine networks, and immune-brain-behavior interactions may help establish PNI profiles for the identification of potential targets for personalized interventions in at risk populations. The understanding of the general systemic pathways among different disorders may contribute to the transition from the disease-centered medicine to patient-centered medicine. Integrative strategies targeting these factors and pathways would be useful for the prevention and treatment of a spectrum of diseases that share the common links. Examples of the translational implications of potential PNI biomarkers and networks in diseases including depression, Alzheimer’s disease, obesity, cardiovascular disease, stroke, and HIV are discussed in details.

This is a preview of subscription content, log in via an institution.

Protocol
USD   49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Springer Nature is developing a new tool to find and evaluate Protocols. Learn more

References

  1. Yan Q (2010) Translational bioinformatics and systems biology approaches for personalized medicine. Methods Mol Biol 662:167–178

    Article  PubMed  CAS  Google Scholar 

  2. Yan Q (2011) Translation of psychoneuroimmunology into personalized medicine: a systems biology perspective. Person Med 8:641–649

    Article  Google Scholar 

  3. Reckow S, Gormanns P, Holsboer F et al (2008) Psychiatric disorders biomarker identification: from proteomics to systems biology. Pharmacopsychiatry 41(suppl 1):S70–S77

    Article  PubMed  CAS  Google Scholar 

  4. Yan Q (2011) Toward the integration of personalized and systems medicine: challenges, opportunities and approaches. Person Med 8:1–4

    Article  Google Scholar 

  5. O’Connor M-F, Bower JE, Cho HJ et al (2009) To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain Behav Immun 23:887–897

    Article  PubMed  Google Scholar 

  6. Dantzer R, Capuron L, Irwin MR (2008) Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology 33:18–29

    Article  PubMed  Google Scholar 

  7. Klengel T, Binder EB (2011) Using gene–environment interactions to target personalized treatment in mood disorder. Person Med 8:23–34

    Article  CAS  Google Scholar 

  8. Yan Q (2008) The integration of personalized and systems medicine: bioinformatics support for pharmacogenomics and drug discovery. Methods Mol Biol 448:1–19

    Article  PubMed  CAS  Google Scholar 

  9. Yan Q (2010) Immunoinformatics and systems biology methods for personalized medicine. Methods Mol Biol 662:203–220

    Article  PubMed  CAS  Google Scholar 

  10. Goncharova LB, Tarakanov AO (2007) Molecular networks of brain and immunity. Brain Res Rev 55:155–166

    Article  PubMed  CAS  Google Scholar 

  11. Zhang Y, Filiou MD, Reckow S et al (2011) Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Mol Cell Proteomics 10(12):M111.008110

    Article  PubMed  Google Scholar 

  12. Gormanns P, Mueller NS, Ditzen C et al (2011) Phenome-transcriptome correlation unravels anxiety and depression related pathways. J Psychiatr Res 45:973–979

    Article  PubMed  Google Scholar 

  13. Sequeira PA, Martin MV, Vawter MP (2012) The first decade and beyond of transcriptional profiling in schizophrenia. Neurobiol Dis 45(1):23–36

    Article  PubMed  CAS  Google Scholar 

  14. Taylor AG, Goehler LE, Galper DI et al (2010) Top-down and bottom-up mechanisms in mind-body medicine: development of an integrative framework for psychophysiological research. Explore (NY) 6:29–41

    Article  Google Scholar 

  15. Yan Q (2011) Understanding and applying personalized therapeutics at systems level: role for translational bioinformatics. Curr Pharmacogenomics Person Med 9:137–147

    Article  CAS  Google Scholar 

  16. Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130:226–238

    Article  PubMed  CAS  Google Scholar 

  17. The systems biology database of cytokines. Available from http://www.pharmtao.com/cytokines. Accessed Jan 2012

  18. Wilson CJ, Finch CE, Cohen HJ (2002) Cytokines and cognition—the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc 50:2041–2056

    Article  PubMed  Google Scholar 

  19. Dean B (2011) Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int J Neuropsychopharmacol 14:997–1012

    Article  PubMed  CAS  Google Scholar 

  20. Zhao J-B, Zhang Y, Li G-Z et al (2011) Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Neurosci Lett 498:147–152

    Article  PubMed  CAS  Google Scholar 

  21. Copf T, Goguel V, Lampin-Saint-Amaux A et al (2011) Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc Natl Acad Sci U S A 108:8059–8064

    Article  PubMed  CAS  Google Scholar 

  22. Pike JL, Irwin MR (2006) Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder. Brain Behav Immun 20:169–174

    Article  PubMed  CAS  Google Scholar 

  23. Blume J, Douglas SD, Evans DL (2011) Immune suppression and immune activation in depression. Brain Behav Immun 25:221–229

    Article  PubMed  CAS  Google Scholar 

  24. Catena-Dell’Osso M, Bellantuono C, Consoli G et al (2011) Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development? Curr Med Chem 18:245–255

    Article  PubMed  Google Scholar 

  25. Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37(1):137–162

    Article  PubMed  CAS  Google Scholar 

  26. Miller AH (2009) Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun 23:149–158

    Article  PubMed  CAS  Google Scholar 

  27. Matsunaga M, Isowa T, Murakami H et al (2009) Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception. Brain Behav Immun 23:931–935

    Article  PubMed  CAS  Google Scholar 

  28. Raison CL, Borisov AS, Woolwine BJ et al (2010) Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol Psychiatry 15:535–547

    Article  PubMed  CAS  Google Scholar 

  29. Oxenkrug GF (2011) Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J Neural Transm 118:75–85

    Article  PubMed  CAS  Google Scholar 

  30. Anisman H, Merali Z, Hayley S (2008) Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog Neurobiol 85:1–74

    Article  PubMed  CAS  Google Scholar 

  31. Capuron L, Su S, Miller AH et al (2008) Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry 64:896–900

    Article  PubMed  CAS  Google Scholar 

  32. Motivala SJ, Sarfatti A, Olmos L et al (2005) Inflammatory markers and sleep disturbance in major depression. Psychosom Med 67:187–194

    Article  PubMed  CAS  Google Scholar 

  33. Thornton LM, Andersen BL, Schuler TA et al (2009) A psychological intervention reduces inflammatory markers by alleviating depressive symptoms: secondary analysis of a randomized controlled trial. Psychosom Med 71:715–724

    Article  PubMed  CAS  Google Scholar 

  34. Irwin MR, Olmstead R, Valladares EM et al (2009) Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence. Biol Psychiatry 66:191–195

    Article  PubMed  CAS  Google Scholar 

  35. Guerreiro RJ, Santana I, Brás JM et al (2007) Peripheral inflammatory cytokines as biomarkers in Alzheimer’s disease and mild cognitive impairment. Neurodegener Dis 4:406–412

    Article  PubMed  CAS  Google Scholar 

  36. Tong L, Balazs R, Soiampornkul R et al (2008) Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging 29:1380–1393

    Article  PubMed  CAS  Google Scholar 

  37. Di Bona D, Plaia A, Vasto S et al (2008) Association between the interleukin-1beta polymorphisms and Alzheimer’s disease: a systematic review and meta-analysis. Brain Res Rev 59:155–163

    Article  PubMed  Google Scholar 

  38. Bossù P, Ciaramella A, Salani F et al (2008) Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment. Brain Behav Immun 22:487–492

    Article  PubMed  Google Scholar 

  39. Lee SJ, Drabik K, Van Wagoner NJ et al (2000) ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. J Immunol 165:4658–4666

    PubMed  CAS  Google Scholar 

  40. Kiyota T, Okuyama S, Swan RJ et al (2010) CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J 24:3093–3102

    Article  PubMed  CAS  Google Scholar 

  41. Strle K, Zhou JH, Shen WH et al (2001) Interleukin-10 in the brain. Crit Rev Immunol 21:427–449

    Article  PubMed  CAS  Google Scholar 

  42. Juhász G, Földi I, Penke B (2011) Systems biology of Alzheimer’s disease: how diverse molecular changes result in memory impairment in AD. Neurochem Int 58:739–750

    Google Scholar 

  43. Olson L, Humpel C (2010) Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment. Exp Gerontol 45:41–46

    Article  PubMed  CAS  Google Scholar 

  44. Ahima RS (2006) Adipose tissue as an endocrine organ. Obesity (Silver Spring) 14(suppl 5):242S–249S

    Article  CAS  Google Scholar 

  45. Zhang F, Chen Y, Heiman M et al (2005) Leptin: structure, function and biology. Vitam Horm 71:345–372

    Article  PubMed  CAS  Google Scholar 

  46. Ahima RS, Qi Y, Singhal NS (2006) Adipokines that link obesity and diabetes to the hypothalamus. Prog Brain Res 153:155–174

    Article  PubMed  CAS  Google Scholar 

  47. Metlakunta AS, Sahu M, Yasukawa H et al (2011) Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. Am J Physiol Regul Integr Comp Physiol 300:R1185–R1193

    Article  PubMed  CAS  Google Scholar 

  48. Capuron L, Poitou C, Machaux-Tholliez D et al (2011) Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med 41:1517–1528

    Article  PubMed  CAS  Google Scholar 

  49. Empana JP, Sykes DH, Luc G et al (2005) Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation 111:2299–2305

    Article  PubMed  CAS  Google Scholar 

  50. Klocke R, Kuhlmann MT, Scobioala S et al (2008) Granulocyte colony-stimulating factor (G-CSF) for cardio- and cerebrovascular regenerative applications. Curr Med Chem 15:968–977

    Article  PubMed  CAS  Google Scholar 

  51. Planas AM, Gorina R, Chamorro A (2006) Signalling pathways mediating inflammatory responses in brain ischaemia. Biochem Soc Trans 34(pt 6):1267–1270

    PubMed  CAS  Google Scholar 

  52. Karikó K, Weissman D, Welsh FA (2004) Inhibition of toll-like receptor and cytokine signaling–a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab 24:1288–1304

    Article  PubMed  Google Scholar 

  53. Zhang W, Stanimirovic D (2002) Current and future therapeutic strategies to target inflammation in stroke. Curr Drug Targets Inflamm Allergy 1:151–166

    Article  PubMed  CAS  Google Scholar 

  54. Cole SW (2008) Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms. Psychosom Med 70:562–568

    Article  PubMed  Google Scholar 

  55. Yang B, Akhter S, Chaudhuri A et al (2009) HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood–brain barrier: modulatory effects of STAT1 signaling. Microvasc Res 77:212–219

    Article  PubMed  CAS  Google Scholar 

  56. Bethel-Brown C, Yao H, Callen S et al (2011) HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. J Immunol 186:4119–4129

    Article  PubMed  CAS  Google Scholar 

  57. Carrico AW, Antoni MH (2008) Effects of psychological interventions on neuroendocrine hormone regulation and immune status in HIV-positive persons: a review of randomized controlled trials. Psychosom Med 70:575–584

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. PharmTao, Santa Clara, CA, USA

    Qing Yan

  2. University of Phoenix, Phoenix, AZ, USA

    Qing Yan

Authors
  1. Qing Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qing Yan .

Editor information

Editors and Affiliations

  1. PharmTao, Lafayette St 4601, Santa Clara, 95056, California, USA

    Qing Yan

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this protocol

Cite this protocol

Yan, Q. (2012). Translational Implications of Inflammatory Biomarkers and Cytokine Networks in Psychoneuroimmunology. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 934. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-071-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-071-7_6

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-070-0

  • Online ISBN: 978-1-62703-071-7

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation