Abstract
Pain is a major symptom of bone cancer. Bone cancer pain significantly affects quality of life, but its underlying mechanisms have not been defined. Because skeletal metastases are particularly common in patients with prostate cancer, a model that mimics bone cancer pain has been established by injecting AT-3.1 prostate cancer cells into the tibia of the male Copenhagen rat. The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders.
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Acknowledgments
The author would like to thank Dr. Lyn Lowry for her editorial support. This work was funded by NIH grant R21 CA102383-01.
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Zhang, R., Lao, L. (2012). A New Rat Model of Bone Cancer Pain. In: Luo, Z. (eds) Pain Research. Methods in Molecular Biology, vol 851. Humana Press. https://doi.org/10.1007/978-1-61779-561-9_20
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DOI: https://doi.org/10.1007/978-1-61779-561-9_20
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