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Nanotechnology in Regenerative Medicine pp 1–16Cite as

Is Nanotechnology the Key to Unravel and Engineer Biological Processes?

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 811))

Abstract

Regenerative medicine is an emerging field aiming to the development of new reparative strategies to treat degenerative diseases, injury, and trauma through developmental pathways in order to rebuild the architecture of the original injured organ and take over its functionality. Most of the processes and interactions involved in the regenerative process take place at subcellular scale. Nanotechnology provides the tools and technology not only to detect, to measure, or to image the interactions between the different biomolecules and biological entities, but also to control and guide the regenerative process. The relevance of nanotechnology for the development of regenerative medicine as well as an overview of the different tools that contribute to unravel and engineer biological systems are presented in this chapter. In addition, general data about the social impact and global investment in nanotechnology are provided.

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References

  1. Gurtner, G.C., Calleghan, M.J., Longaker, M.T. (2007) Progress and Potential for Regenerative Medicine, Annu. Rev. Med. 58, 299–312

    Article  CAS  Google Scholar 

  2. Nanomedicine, Nanotechnology for health, (2006) ETP Strategic Research Agenda for Nanomedicine, Available online at: http://cordis.europa.eu/nanotechnology/nanomedicine.htm

  3. Haseltine, W. (2003) Regenerative medicine 2003: An overview, J Regener Med 4, 15–18

    Google Scholar 

  4. Mironov, V., Visconti, R.P., Markwald, R.R. (2004) What is regenerative medicine? Emergence of applied stem cell and developmental biology, Expert Opin Biol Ther 4, 773–781

    CAS  Google Scholar 

  5. Hardouin, P., Anselme, K., Flautre, B., Bianchi, F., Bascoulenguet, G. & Bouxin, B. (2000) Tissue engineering and skeletal diseases. Joint Bone Spine 67, 419–424

    CAS  Google Scholar 

  6. Silva, G.A., Introduction to nanotechnology an its applications to medicine, Surg Neurol 61, 216–220

    Google Scholar 

  7. Craighead, H., Leong, K. (2000). Biological, medical and health applications. In: Research Directions, Roco, M.C., Williams, R.S., Alivisatos, P (eds) Kluwer Academic Publishers

    Google Scholar 

  8. Whitesides, G.M. (2003) The “right” size in nanobiotechnology, Nat Biotechnol 18, 760–763

    Google Scholar 

  9. Nienmeyer, C.M., Mirkin, C.A. eds (2004) Nanobiotechnology: Concepts, Applications and Perspectives, Wiley

    Google Scholar 

  10. Roco, M. (2005) Converging Technologies In: Biomedical Nanotechnology, Malsch, N.H. (ed) CRC Press

    Google Scholar 

  11. Roco, M.C., Bainbridge, W.S. (eds) Converging Technologies for Improving Human Performance. NSF-DOC Report, 2002; Kluwer: Boston. URL: http//wtec.org/ConvergingTechnologies

  12. National Research Council: Small wonders-endless frontiers, a review of the National Nanotechnology Initiative. The National Academies Press, Washington DC; 2002. Available online at: URL: http//www.nsf.gov/home/cressprgm/nano/smallwonders_pdffiles.htm

  13. National Research Council: Implications of emerging micro and nanotechnologies. The National Academies Press, Washington DC, 2002

    Google Scholar 

  14. Macchiarini, P., Jungebluth, P., Go, T., Asnaghi, M.A., Rees, L.E., Cogan, T.A., Dodson, A., Martorell, J., Bellini, S., Parnigotto, P.P., Dickinson, S.C., Hollander, A.P., Mantero, A., Conconi, M.T., Birchall, M.A. (2008) Clinical transplantation of a tissue-engineered airway, Lancet 372, 2023–2030

    Article  Google Scholar 

  15. Zhang, G., Hu, Q., Braunlin, E.A., Suggs, L.J., Zhang, J. (2010) Enhancing Efficacy of Stem Cell Transplantation to the Heart with a PEGylated Fibrin Biomatrix, Advances in Tissue Engineering: Angiogenesis 20, 195–205

    CAS  Google Scholar 

  16. European Technology Platform on Nanomedicine, Nanotechnology for health (2005) European Commission, Luxembourg. Available online at: http://cordis.europa.eu/nanotechnology/nanomedicine.htm

  17. Ishima, A., Yanagida, T. (2001) Single molecule nanobioscience, Trends Biochem Sci 26, 438–444

    Article  Google Scholar 

  18. Müller, D.J., Janovjak, H., Lehto, T., Kuerschner, L., Anderson, K. (2002) Observing structure, function and assembly of single proteins by AFM, Prog Biophys Mol Biol 79, 1–43

    Article  Google Scholar 

  19. Misevic, G.N. (2001) Atomic force microscopy measurements: binding strength between a single pair of molecules in physiological solutions, Mol Biotechnol 18, 149–154

    Article  CAS  Google Scholar 

  20. Bao, G. (2002) Mechanics of Biomolecules, J Mechanics Phys Solids 50, 2237–2274

    Article  CAS  Google Scholar 

  21. Ikai, A., Idiris, A., Sekiguchi, H., Arakawa, H., Nishida, S. (2002) Intra and intermolecular mechanics of proteins and polypeptides studies by AFM. Appl Surf Sci 188, 506–512

    Article  CAS  Google Scholar 

  22. Baneyx, G., Baugh, L., Vogel, V. (2001) Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transfer, Proc Natl Acad Sci USA 98; 14464–14468

    Article  CAS  Google Scholar 

  23. Lower, S.K., Hochella, M.F.H., Beveridge, T.J. (2001) Bacterial recognition of mineral surfaces: nanoscale interactions between Shewanella and alpha-FEDOH, Science 292, 1360–1363

    Article  CAS  Google Scholar 

  24. Couzin, J. (2002) Breakthrough of the year: small RNAs make big splash, Science 298, 2296–2297

    Article  CAS  Google Scholar 

  25. Jain, K.K. (2007) Nanobiotechnology: Applications, Markets and Companies. Basel: Jain (Ed) PharmaBiotech Publications

    Google Scholar 

  26. Bao, Y.P., Wei, T.F., Lefebvre, P.A., An, H., He, L., Kunkel, G.T. (2006) Detection of protein analytes via nanoparticle-based bio bar code technology. Anal Chem 78, 2055–2059

    Article  CAS  Google Scholar 

  27. Davis, A.V., Yeh, R.M., Raymond, K.N. (2002) Supramolecular assembly dynamics, Proc Natl Acad Sci USA 99, 4793–4796

    Article  CAS  Google Scholar 

  28. Whitesides, G., Boncheva, M. (2002) Beyond molecules: self assembling of mesoscopic and macroscopic component, Proc Natl Acad Sci USA 99, 4769–4774

    Article  CAS  Google Scholar 

  29. Geho, D.H., Jones, C.D., Petricoin, E.F., Liotta, L.A. (2006) Nanoparticles: potential biomarker harvesters. Curr Opin Chem Biol 10, 56–61

    Article  CAS  Google Scholar 

  30. Chan, W.C., Maxwell, D.J., Gao, X., Bailey, R.E., Han, M., Nie, S. (2002) Luminiscent quantum dots for multiplexed biological detection and imaging, Curr Opin Biotechnol 13, 40–46

    Article  CAS  Google Scholar 

  31. Lin, Y., Taylor, S., Huaping, L., Shiral, K. A., Qu, L., Wang, W., Gu, L., Zhou B., Sun Y-P., (2004) Advances toward bioapplications of carbon nanotubes, J Mater Chem 14, 527–541 K

    Google Scholar 

  32. Ciofani, G., Raffa, V., Menciassi, A., and Cuschieri, A. (2009) Boron nitride nanotubes: an innovative tool for nanomedicine. Nano Today 4, 8–10

    Article  CAS  Google Scholar 

  33. Jain, K.K. (2005) Nanotechnology-based lab-on-a-chip devices. In: Fuchs J, Podda M. (eds). Encyclopedia of Diagnostic Genomics and Proteomics, New York: Marcel Dekkar Inc

    Google Scholar 

  34. Roco, M.C. (2001) International strategy for nanotechnology research and development, J Nanoparticle Res 3, 353–360

    Article  Google Scholar 

  35. The National Nanotechnology Initiative, Supplement to the president’s 2011 budget, National Science and Technology Council, USA 2010. Available online at: http://www.nano.gov/NNI_2011_budget_supplement.pdf

  36. National nanotechnology strategy annual report 2008–2009 (2009) Australian office of nanotechnology

    Google Scholar 

  37. Nanotechnology in Australia, Trends, applications and collaborative opportunities (2009) Australian Academy of Science http://www.science.org.au/reports/documents/nanotechnology09.pdf

  38. European Commission, EU Policy for nanosciences and nanotechnologies. Available online at: ftp://ftp.cordis.europa.eu/pub/nanotechnology/docs/eu_nano_policy_2004-07.pdf

  39. Nanotechnology Strategy in Korea, (2003) Asia Pacific Nanotechnology Weekly 1, Nanotechnology Research Institute, AIST. Available online at: http://www.nanoworld.jp/apnw/articles/library/pdf/27.pdf

  40. Kishi, T., Bando, Y. (2004) Status and trends of nanotechnology R&D in Japan. Nat Materials 3, 129–131

    Article  CAS  Google Scholar 

  41. Okada, S. (2009) Big on nanotech: Japan is one of the world leaders in nanotechnology, but its position could be threatened by a lack of govern, Entrepreneur. Available online at: http://www.entrepreneur.com/tradejournals/article/print/201599863.html 2010

  42. Roadmap in nanomedicine towards 2020. Expert report 2009, ETP Nanomedicine, European Commission. Available online at: http://www.etp-nanomedicine.eu/public/press-documents/publications/etpn-publications/091022_ETPN_Report_2009.pdf

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Author information

Authors and Affiliations

  1. Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

    Melba Navarro & Josep A. Planell

  2. Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Barcelona, Spain

    Melba Navarro & Josep A. Planell

Authors
  1. Melba Navarro
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  2. Josep A. Planell
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Corresponding author

Correspondence to Melba Navarro .

Editor information

Editors and Affiliations

  1. (IBEC), Inst. for Bioengineering of Catalonia, C/Baldiri Reixac 10-12, Barcelona, 08028, Spain

    Melba Navarro

  2. (IBEC), Inst. for Bioengineering of Catalonia, C/Baldiri Reixac 10-12, Barcelona, 08028, Spain

    Josep A. Planell

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Navarro, M., Planell, J.A. (2012). Is Nanotechnology the Key to Unravel and Engineer Biological Processes?. In: Navarro, M., Planell, J. (eds) Nanotechnology in Regenerative Medicine. Methods in Molecular Biology, vol 811. Humana Press. https://doi.org/10.1007/978-1-61779-388-2_1

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  • DOI: https://doi.org/10.1007/978-1-61779-388-2_1

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-387-5

  • Online ISBN: 978-1-61779-388-2

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