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Animal Models of Movement Disorders pp 321–342Cite as

The Role of the Pedunculopontine Tegmental Nucleus in Motor Disorders

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Part of the book series: Neuromethods ((NM,volume 62))

Abstract

In this chapter, we discuss why the pedunculopontine is an appropriate target in studying movement disorders, explaining its association with both the pathology and treatment of Parkinsonism. We discuss how various laboratories, including our own, have approached experimental examination of the pedunculopontine and some of the findings that have emerged. These lead us finally to reflect on the nature of movement disorders and how they necessarily involve not just the control of musculature but additionally the complex cognitive processes of decision making – the processes that underlie not just “doing” but also “choosing” and how these are embedded deeper in brain than is often appreciated.

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Acknowledgements

The authors acknowledge the assistance of Duncan MacLaren in preparing this chapter. Work in our lab is supported by grants from the Wellcome Trust (081128/Z/06/Z) and the Medical Research Council (G0901332).

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  1. Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, UK

    Nadine K. Gut & Philip Winn

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  1. Nadine K. Gut
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Correspondence to Nadine K. Gut .

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  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Gut, N.K., Winn, P. (2011). The Role of the Pedunculopontine Tegmental Nucleus in Motor Disorders. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 62. Humana Press. https://doi.org/10.1007/978-1-61779-301-1_17

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