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Biomedical Nanotechnology

Volume 726 of the series Methods in Molecular Biology pp 179-185

Date:

Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles

  • Ghanashyam Acharya
  • , Matthew McDermott
  • , Soo Jung Shin
  • , Haesun Park
  • , Kinam ParkAffiliated withDepartments of Biomedical Engineering and Pharmaceutics, Purdue UniversityAkina Inc. Email author 

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Abstract

Nano/microparticulate drug delivery systems with homogeneous size distribution and predefined shape are important in understanding the influence of the geometry and dimensions of these systems on blood circulation times and cellular uptake. We present a general method using water dissolvable hydrogel templates for the fabrication of homogeneous, shape-specific polymer/drug constructs in the size range of 200 nm to 50 μm. This hydrogel template strategy is mild, inexpensive, and readily scalable for the fabrication of multifunctional drug delivery vehicles.

Key words

Hydrogel Gelatin Template PLGA Microparticle