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Bioinformatics for Omics Data

Volume 719 of the series Methods in Molecular Biology pp 173-196

Date:

The Use and Abuse of -Omes

  • Sonja J. ProhaskaAffiliated withDepartment of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig
  • , Peter F. StadlerAffiliated withDepartment of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig Email author 

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Abstract

The diverse fields of Omics research share a common logical structure combining a cataloging effort for a particular class of molecules or interactions, the underlying -ome, and a quantitative aspect attempting to record spatiotemporal patterns of concentration, expression, or variation. Consequently, these fields also share a common set of difficulties and limitations. In spite of the great success stories of Omics projects over the last decade, much remains to be understood not only at the technological, but also at the conceptual level. Here, we focus on the dark corners of Omics research, where the problems, limitations, conceptual difficulties, and lack of knowledge are hidden.

Key words

Omics Systems biology Data integration Annotation Assumptions Limitations