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Drill Hole Defects: Induction, Imaging, and Analysis in the Rodent

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Book cover Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 690))

Abstract

Advances in stem therapy, scaffolds, and therapeutic biomolecules are accelerating bone repair research, and model systems are required to test new methods and concepts. The drill hole defect is one such model and is used to study a variety of bone defects and potential therapies designed to repair these injuries. We detail the methodologies required to successfully generate and evaluate drill hole defects. Although performing a successful drill hole defect requires patience and dexterity, investing the time to perfect the technique will provide ample opportunity for the researcher to expand his/her particular research interests. Mastering this technique will allow testing of stem cell therapies, novel scaffold designs, and biomolecules that can be used for clinical translation.

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Authors and Affiliations

  1. Non-Invasive Imaging Laboratory, Department of Biophysics and Bioengineering, Departments of Radiation Medicine, Pediatrics, and Radiology, School of Medicine, School of Science and Technology, Loma Linda University, Loma Linda, CA, USA

    Andre Obenaus

  2. Non-Invasive Imaging Laboratory, Departments of Radiation Medicine, Pediatrics, and Radiology, Department of Biophysics and Bioengineering, School of Medicine, School of Science and Technology, Loma Linda University, Loma Linda, CA, USA

    Pedro Hayes

Authors
  1. Andre Obenaus
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  2. Pedro Hayes
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Correspondence to Andre Obenaus .

Editor information

Editors and Affiliations

  1. Dept. of Cell Biology & Neuroscience, University of California at Riverside, University Ave. 900, Riverside, 92521, California, USA

    Nicole I. Nieden

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Obenaus, A., Hayes, P. (2011). Drill Hole Defects: Induction, Imaging, and Analysis in the Rodent. In: Nieden, N. (eds) Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases. Methods in Molecular Biology, vol 690. Humana Press. https://doi.org/10.1007/978-1-60761-962-8_20

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  • DOI: https://doi.org/10.1007/978-1-60761-962-8_20

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-961-1

  • Online ISBN: 978-1-60761-962-8

  • eBook Packages: Springer Protocols

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