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PET Imaging of αvβ3 Expression in Cancer Patients

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Book cover Molecular Imaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 680))

Abstract

Imaging of αvβ3 expression in malignant diseases has been extensively studied in the last years, mainly because the level of integrin αvβ3 expression might be a surrogate parameter of angiogenic activity. Most studies have been performed using preclinical tumor models but recently first results if imaging αvβ3 expression in patients have been published. The first approach used was the radiotracer approach with tracers for positron emission tomography (PET) like [18F]Galacto-RGD or tracers for single photon emission computed tomography (SPECT) like [99mTc]NC100692. In this article we will focus on the experimental design and methodology of PET imaging of αvβ3 expression with the tracer [18F]Galacto-RGD. Common difficulties and pitfalls in image acquisition and interpretation will be discussed. Finally, the performance of PET will be compared to other methods of imaging of αvβ3 expression, like magnetic resonance imaging, ultrasound, or optical imaging.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, 81675, Germany

    Ambros J. Beer & Markus Schwaiger

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  1. Ambros J. Beer
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  2. Markus Schwaiger
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Correspondence to Ambros J. Beer .

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Editors and Affiliations

  1. Massachusetts General Hospital, Department of Radiology and Neurology, Harvard Medical School, Charlestown, 02129-2060, Massachusetts, USA

    Khalid Shah

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© 2011 Humana Press

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Beer, A.J., Schwaiger, M. (2011). PET Imaging of αvβ3 Expression in Cancer Patients. In: Shah, K. (eds) Molecular Imaging. Methods in Molecular Biology, vol 680. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-901-7_13

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  • DOI: https://doi.org/10.1007/978-1-60761-901-7_13

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-900-0

  • Online ISBN: 978-1-60761-901-7

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