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Diagnostic Virology Protocols pp 123–132Cite as

HIV Drug Resistance Testing

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  • First Online:

Part of the book series: Methods in Molecular Biology ((MIMB,volume 665))

Abstract

HIV genotypic resistance testing has become a routine test informing the management of HIV-positive patients. This chapter describes the background of this testing and provides a protocol for undertaking the assay by a home-brew method. Methods for interpretation of the data are also outlined.

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References

  1. Gazzard, B.G. (2008) BHIVA treatment guidelines writing group. British HIV association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy. HIV Med 9, 563–608.

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  2. http://www.who.int/drugresistance/hivaids/en/index.html.

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  4. http://www.hivdrugresistance.com/.

  5. Buckton, A.J., Bissett, S.L., Myers, R.E., Beddows, S., Cane, P.A., and Pillay, D. (2008) Development and optimization of an internally controlled dried blood spot assay for surveillance of human immunodeficiency virus type-1 drug resistance. J Antimicrob Chemother 62(6), 1191–1198.

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  6. Shafer, R.W. and Schapiro, J.M. (2008) HIV-1 drug resistance mutations: an updated framework for the second decade of HAART. AIDS Rev 10, 67–84.

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  7. http://hivdb.stanford.edu.

  8. http://www.geno2pheno.org/cgi-bin/geno2pheno.pl.

  9. Cane, P.A., Kaye, S., Smit, E., Tilston, P., Kirk, S., Shepherd, J., Hopkins, M., Zhang, H., and Geretti, A.M. (2008) Genotypic antiretroviral drug resistance testing at low viral loads in the UK. HIV Med 9, 673–676.

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  10. http://www.QCMD.co.uk.

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Author information

Authors and Affiliations

  1. Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK

    Patricia Cane

Authors
  1. Patricia Cane
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Corresponding author

Correspondence to Patricia Cane .

Editor information

Editors and Affiliations

  1. , Research & Development Division, Health Protection Agency, High Holborn 330, London, WC1V 7BA, United Kingdom

    John R. Stephenson

  2. Northwick Park Hospital, Research and Development, North West London Hospitals NHS Trust, Watford Road, Harrow, HA13UJ, Middlesex, United Kingdom

    Alan Warnes

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Cane, P. (2010). HIV Drug Resistance Testing. In: Stephenson, J., Warnes, A. (eds) Diagnostic Virology Protocols. Methods in Molecular Biology, vol 665. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-817-1_8

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  • DOI: https://doi.org/10.1007/978-1-60761-817-1_8

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-816-4

  • Online ISBN: 978-1-60761-817-1

  • eBook Packages: Springer Protocols

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