Abstract
Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.
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We thank Drs. David Tarlinton and Louise McKenzie for critical reading of the manuscript, and Ozgene scientific staff for fruitful discussions.
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Koentgen, F., Suess, G., Naf, D. (2010). Engineering the Mouse Genome to Model Human Disease for Drug Discovery. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 602. Humana Press. https://doi.org/10.1007/978-1-60761-058-8_4
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