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Target Selection: Triage in the Structural Genomics Battlefield

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Structural Proteomics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 426))

 

A synopsis of some of the approaches to protein target selection is given, with an emphasis on using web resources to converge on well-ordered, readily crystallizable proteins that are maximally different from known structures. This is illustrated with the genomes of the pathogens causing tuberculosis and sleeping sickness.

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Acknowledgments

The author thanks John R. Helliwell for detailed discussions. This chapter is a contribution to the UK North West Structural Genomics Consortium (NWSGC) coordinated by S. S. Hasnain, CCLRC Daresbury Laboratory, UK.

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Authors and Affiliations

  1. School of Chemistry, The University of Manchester, Manchester, UK

    James Raftery

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  1. James Raftery
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Editors and Affiliations

  1. School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia

    Bostjan Kobe

  2. School of Molecular and Microbial Biosciences, University of Sydney, Sydney, Australia

    Mitchell Guss

  3. School of Molecular and Microbial Sciences and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia

    Thomas Huber

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Raftery, J. (2008). Target Selection: Triage in the Structural Genomics Battlefield. In: Kobe, B., Guss, M., Huber, T. (eds) Structural Proteomics. Methods in Molecular Biology™, vol 426. Humana Press. https://doi.org/10.1007/978-1-60327-058-8_3

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  • DOI: https://doi.org/10.1007/978-1-60327-058-8_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-809-6

  • Online ISBN: 978-1-60327-058-8

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