Protocol

Antimicrobial Peptides

Volume 1548 of the series Methods in Molecular Biology pp 427-435

Date:

Hemolytic Activity of Antimicrobial Peptides

  • Alberto OddoAffiliated withDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen
  • , Paul R. HansenAffiliated withDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen Email author 

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Abstract

For antimicrobial peptides to be interesting for systemic applications, they must show low toxicity against erythrocytes. In this chapter, we describe a protocol for measuring the ability of AMPs to lyse human red blood cells, using melittin as positive control.

Key words

Antimicrobial peptides Hemolysis Red blood cells Melittin