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Bacterial Pathogenesis pp 65–75Cite as

Competition for Iron Between Host and Pathogen: A Structural Case Study on Helicobacter pylori

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1535))

Abstract

Helicobacter pylori (H. pylori) is a highly successful bacterial pathogen, which colonizes the stomach of more than half of the world’s population. To colonize and survive in such an acidic and inhospitable niche, H. pylori cells have evolved complex mechanisms to acquire nutrients from human hosts, including iron, an essential nutrient for both the pathogens and host cells. However, human cells also utilize diverse strategies in withholding of irons to prevent the bacterial outgrowth. The competition for iron is the central battlefield between pathogen and host. This mini-review summarizes the updated scenarios of the battle for iron between H. pylori and human host from a structural biology perspective.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (21501200) and a starting fund from Sun Yat-sen University.

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Authors and Affiliations

  1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, 135 West Xingang Road, Guangzhou 510275, China

    Wei Xia

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  1. Wei Xia
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Correspondence to Wei Xia .

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Editors and Affiliations

  1. Department of Clinical Sciences, Lund University, Division of Infection Medicine, Lund, Sweden

    Pontus Nordenfelt

  2. Department of Clinical Sciences, Lund University, Division of Infection Medicine, Lund, Sweden

    Mattias Collin

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Xia, W. (2017). Competition for Iron Between Host and Pathogen: A Structural Case Study on Helicobacter pylori . In: Nordenfelt, P., Collin, M. (eds) Bacterial Pathogenesis. Methods in Molecular Biology, vol 1535. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6673-8_5

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  • DOI: https://doi.org/10.1007/978-1-4939-6673-8_5

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6671-4

  • Online ISBN: 978-1-4939-6673-8

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