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Decellularization of Bovine Small Intestinal Submucosa

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Book cover Decellularized Scaffolds and Organogenesis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1577))

Abstract

Decellularization technology promises to overcome some of the significant limitations in the regenerative medicine field by providing functional biocompatible grafts. The technique involves removal of the cells from the biological tissues or organs for further use in tissue engineering and clinical interventions. There are significant differences between decellularization protocols due to the intrinsic properties of different tissue types and purpose of use. This multistep, chemical-solution-based protocol is optimized for the preparation of decellularized bovine small intestinal submucosa (SIS).

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Competing Interests

Y.M.E. is the founder of Biovalda, Inc. (Ankara, Turkey) and has intellectual properties related to decellularized tissues.

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Authors and Affiliations

  1. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Ankara, Turkey

    Mahmut Parmaksiz & Ayşe Eser Elçin

  2. Biovalda Health Technologies, Inc., Ankara, Turkey

    Yaşar Murat Elçin

  3. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, Ankara, Turkey

    Yaşar Murat Elçin

Authors
  1. Mahmut Parmaksiz
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  2. Ayşe Eser Elçin
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  3. Yaşar Murat Elçin
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Corresponding author

Correspondence to Yaşar Murat Elçin .

Editor information

Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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© 2017 Springer Science+Business Media New York

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Parmaksiz, M., Elçin, A.E., Elçin, Y.M. (2017). Decellularization of Bovine Small Intestinal Submucosa. In: Turksen, K. (eds) Decellularized Scaffolds and Organogenesis. Methods in Molecular Biology, vol 1577. Humana Press, New York, NY. https://doi.org/10.1007/7651_2017_33

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  • DOI: https://doi.org/10.1007/7651_2017_33

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7655-3

  • Online ISBN: 978-1-4939-7656-0

  • eBook Packages: Springer Protocols

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