Protocol

Skeletal Development and Repair

Volume 1130 of the series Methods in Molecular Biology pp 35-44

Date:

Generation of Closed Transverse Fractures in Small Animals

  • Anthony De GiacomoAffiliated withBoston University School of Medicine
  • , Elise F. MorganAffiliated withBoston University School of Medicine
  • , Louis C. GerstenfeldAffiliated withBoston University School of Medicine

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Abstract

The most common procedure that has been developed for use in rats and mice to model fracture healing is described. The nature of the regenerative processes that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented, and general considerations when setting up an experiment using this model are described.

Keywords

Fracture Healing Surgical Model Rodent