miRNomics: MicroRNA Biology and Computational Analysis

Volume 1107 of the series Methods in Molecular Biology pp 311-325


Use of MicroRNAs in Personalized Medicine

  • Çiğir Biray AvciAffiliated withFaculty of Medicine, Department of Medical Biology, Ege University
  • , Yusuf BaranAffiliated withMolecular Biology and Genetics, Izmir Institute of Technology

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Personalized medicine comprises the genetic information together with the phenotypic and environmental factors to yield healthcare tailored to an individual and removes the limitations of the “one-size-fits-all” therapy approach. This provides the opportunity to translate therapies from bench to clinic, to diagnose and predict disease, and to improve patient-tailored treatments based on the unique signatures of a patient’s disease and further to identify novel treatment schedules.

Nowadays, tiny noncoding RNAs, called microRNAs, have captured the spotlight in molecular biology with highlights like their involvement in DNA translational control, their impression on mRNA and protein expression levels, and their ability to reprogram molecular signaling pathways in cancer. Realizing their pivotal roles in drug resistance, they emerged as diagnostic targets orchestrating drug response in individualized therapy examples.

It is not premature to think that researchers could have the US Food and Drug Administration (FDA)-approved kit-based assays for miRNA analysis in the near future. We think that miRNAs are ready for prime time.


miRNAs Personalized medicine Pharmacogenomics