Protocol

Wound Regeneration and Repair

Volume 1037 of the series Methods in Molecular Biology pp 265-274

Date:

Murine Models of Human Wound Healing

  • Jerry S. ChenAffiliated withDepartment of Surgery, Stanford University
  • , Michael T. LongakerAffiliated withDepartment of Surgery, Stanford UniversityHagey Laboratory for Pediatric and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
  • , Geoffrey C. GurtnerAffiliated withHagey Laboratory for Pediatric and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine

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Abstract

In vivo wound healing experiments remain the most predictive models for studying human wound healing, allowing an accurate representation of the complete wound healing environment including various cell types, environmental cues, and paracrine interactions. Small animals are economical, easy to maintain, and allow researchers to take advantage of the numerous transgenic strains that have been developed to investigate the specific mechanisms involved in wound healing and regeneration. Here we describe three reproducible murine wound healing models that recapitulate the human wound healing process.

Key words

Wound healing Mouse model Excisional wound Ischemic wound Pressure ulcer