Protocol

Transplantation Immunology

Volume 1034 of the series Methods in Molecular Biology pp 117-125

Date:

Transplantation of the Sensitized Patient: Histocompatibility Testing

  • Robert A. MontgomeryAffiliated withDepartment of Surgery, Johns Hopkins University School of Medicine
  • , Mary S. LeffellAffiliated withImmunogenetics Laboratory, Department of Medicine, Johns Hopkins University School of Medicine
  • , Andrea A. ZacharyAffiliated withImmunogenetics Laboratory, Department of Medicine, Johns Hopkins University School of Medicine

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Abstract

A component necessary for successful transplantation of the sensitized patient is timely and high quality support from the histocompatibility laboratory that helps guide selection of the best route to transplantation and the clinical care of the patient. Responsibilities of the laboratory include risk assessment, HLA typing, and accurate antibody characterization.

Key words

Antibody monitoring CDC crossmatch Desensitization Flow cytometric crossmatch Kidney paired donation Risk assessment Sensitized patients Solid phase immunoassays Virtual crossmatch