Mouse Models of Innate Immunity

Volume 1031 of the series Methods in Molecular Biology pp 189-195


Dextran Sodium Sulfate-Induced Murine Inflammatory Colitis Model

  • Monika SchneiderAffiliated withInfectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute

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Colitis is a chronic inflammatory disease of the colon that is characterized by recurring, acute episodes. Mouse models of colitis allow for the study of multiple aspects of this disease, including the innate immune response, epithelial and intestinal cell response, and wound healing. The following protocols cover acute, chronic, and cancer-associated colitis models.

Key words

IBD Colon cancer Inflammation-induced tumorigenesis DSS AOM Azoxymethane