Stroke is one of the leading causes of acquired motor disability worldwide. With no cure, the only way to recover motor function is through rehabilitation. Recent trials of Wii-based movement therapy have demonstrated improved functional ability that has transferred to greater independence in activities of daily living. This brief but intense 2-week programme can be tailored to the deficits of individual patients to promote motor recovery. More recent studies have investigated changes in electromyography and joint movement during Wii-based movement therapy. Results from a heterogeneous group of stroke patients suggest that improved movement ability and motor control are promoted by functionally relevant changes in patterns of muscle activation and joint movement.