Date: 09 Oct 2012

Fetal Soft Tissue Examinations by Microdissection

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This chapter describes methods for the examination of fetal abdominal and thoracic soft tissues by microdissection on either fresh (non-rodent) or fixed (rodent) specimens in order to detect structural abnormalities. With hundreds of fetuses examined for each species (rodent and non-rodent) in regulatory reproductive toxicity assessments (ICH,, 2009; ICH,, 2005), microdissection techniques allow a thorough and relatively rapid examination of fetuses for soft tissue abnormalities.