Protocol

Stem Cell Mobilization

Volume 904 of the series Methods in Molecular Biology pp 243-252

Date:

Progenitor Cell Mobilization from Extramedullary Organs

  • Mikhail G. KoloninAffiliated withInstitute of Molecular Medicine, University of Texas Health Science Center at Houston Email author 

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Abstract

The course of various pathological conditions relies on the mobilization of stem cells and partially differentiated progenitor cells. Bone marrow transplantation studies have demonstrated that medullary hematopoietic and endothelial progenitors can undergo mobilization and trafficking. While the ability of the bone marrow to boost its resources in fighting disease or repairing injury declines with age, other organs have surfaced as reservoirs of various progenitor cell populations. This chapter discusses our current understanding of non-bone marrow-derived progenitor pools, focusing on mesenchymal stem cells. The evidence for the extramedullary progenitor mobilization, with a specific emphasis on white adipose tissue, is presented.

Key words:

Progenitor cell Stem cell Mobilization Circulation Bone marrow Extramedullary