Volume 885 of the series Methods in Molecular Biology pp 105-123


Production of Transgenic and Knockout Pigs by Somatic Cell Nuclear Transfer

  • Angelica M. GiraldoAffiliated withRevivicor, Inc.DeSoto Biosciences Inc. Email author 
  • , Suyapa BallAffiliated withRevivicor, Inc.
  • , Kenneth R. BondioliAffiliated withLouisiana State University Agricultural Center, School of Animal Sciences

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Xenotransplantation is one alternative to transplantation of human organs which has been investigated. It is generally accepted that the pig represents the most logical choice of animals to serve as organ donors for xenotransplantation. Moreover, the implementation of cloning by somatic cell nuclear transfer (SCNT) and transgenic techniques have resulted in the production of numerous transgenic pigs than can be used for xenotransplantation purposes as well as models for human diseases.

Key words

Cloning Somatic cell nuclear transfer Transgenesis Knockout Pig engineering