Protocol

Psychiatric Disorders

Volume 829 of the series Methods in Molecular Biology pp 231-242

Date:

Rat Models of Prenatal and Adolescent Cannabis Exposure

  • Jennifer A. DiNieriAffiliated withDepartments of Psychiatry, Pharmacology & Systems Therapeutics, and Neuroscience, Mount Sinai School of Medicine
  • , Yasmin L. HurdAffiliated withDepartments of Psychiatry, Pharmacology & Systems Therapeutics, and Neuroscience, Mount Sinai School of Medicine Email author 

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Abstract

Marijuana (Cannabis sativa) is the illicit drug most commonly used by two vulnerable populations relevant to neurodevelopment—pregnant women and teenagers. Human longitudinal studies have linked prenatal and adolescent cannabis exposure with long-term behavioral abnormalities as well as increased vulnerability to neuropsychiatric disorders in adulthood. Animal models provide a means of studying the neurobiological mechanisms underlying these long-term effects. This chapter provides an overview of the animal models we have used to study the developmental impact of cannabis.

Key words

Δ-9-Tetrahydrocannabinol Cannabinoid Drug addiction Neurodevelopment Perinatal