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Bacterial Molecular Networks

Volume 804 of the series Methods in Molecular Biology pp 1-11

Date:

Bacterial Molecular Networks: Bridging the Gap Between Functional Genomics and Dynamical Modelling

  • Jacques van HeldenAffiliated withLaboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe), Université Libre de Bruxelles Email author 
  • , Ariane ToussaintAffiliated withLaboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe), Université Libre de Bruxelles
  • , Denis ThieffryAffiliated withInstitut de Biologie de l’Ecole Normale Supérieure (IBENS), UMR ENS, CNRS 8197, INSERM 1024

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Abstract

This introductory review synthesizes the contents of the volume Bacterial Molecular Networks of the series Methods in Molecular Biology. This volume gathers 9 reviews and 16 method chapters describing computational protocols for the analysis of metabolic pathways, protein interaction networks, and regulatory networks. Each protocol is documented by concrete case studies dedicated to model bacteria or interacting populations. Altogether, the chapters provide a representative overview of state-of-the-art methods for data integration and retrieval, network visualization, graph analysis, and dynamical modelling.

Key words

Protein interactions Metabolic pathways Regulatory networks Graph motifs Clustering Dynamical modelling Bacteria Metagenomics Computational biology Bioinformatics Systems biology