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Yeast Systems Biology

Volume 759 of the series Methods in Molecular Biology pp 307-319

Date:

Nutritional Control of Cell Growth via TOR Signaling in Budding Yeast

  • Yuehua WeiAffiliated withGraduate Program in Cellular and Molecular Pharmacology, Department of Pharmacology, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School
  • , X.F. Steven ZhengAffiliated withDepartment of Pharmacology, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School Email author 

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Abstract

Cell growth is highly regulated and its deregulation is related to many human diseases such as cancer. Nutritional cues stimulate cell growth through modulation of TOR (target of rapamycin) signaling pathway. At the center of this pathway is a large serine/threonine protein kinase TOR, which forms two distinct functional complexes TORC1 and TORC2 in a cell. TORC1 senses the environmental nutrient quality/quantity and transmits the growth signals to multiple effectors to regulate a broad spectrum of biological processes including translation initiation, ribosome biogenesis, autophagy, nutrient uptake, and metabolism. By using budding yeast as a model, recent studies began to elucidate the complexity of the TOR signaling pathway.

Key words

TOR (target of rapamycin) signal transduction budding yeast cell growth nutrient nutrition ribosome biogenesis autophagy protein translation