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Stem Cell Migration

Volume 750 of the series Methods in Molecular Biology pp 3-24

Date:

Trafficking of Stem Cells

  • Claire MagnonAffiliated withDepartments of Medicine, Gene and Cell Medicine, Tisch Cancer Institute, Immunology Institute and Black Family Stem Cell Institute, Mount Sinai School of Medicine
  • , Daniel LucasAffiliated withDepartments of Medicine, Gene and Cell Medicine, Tisch Cancer Institute, Immunology Institute and Black Family Stem Cell Institute, Mount Sinai School of Medicine
  • , Paul S. FrenetteAffiliated withDepartments of Medicine, Gene and Cell Medicine, Tisch Cancer Institute, Immunology Institute and Black Family Stem Cell Institute, Mount Sinai School of Medicine Email author 

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Abstract

Stem cells undergo regulated trafficking from the developmental stages to the adulthood. Stem cell migration is critical to organize developing organs and likely contributes postnatally to tissue regeneration. Here, we review the molecular mechanisms underlying migration of hematopoietic stem cells, neural stem cells, and primordial germ cells, revealing common operative pathways.

Key words

Stem cell Trafficking Development Tissue regeneration