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The Blood-Brain and Other Neural Barriers

Volume 686 of the series Methods in Molecular Biology pp 49-68

Date:

Morphology and Properties of Pericytes

  • Paula Dore-DuffyAffiliated withDepartment of Neurology, Wayne State University School of Medicine Email author 
  • , Kristen ClearyAffiliated withDepartment of Neurology, Wayne State University School of Medicine

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Abstract

Pericytes were described in 1873 by the French scientist Charles-Marie Benjamin Rouget and were originally called Rouget cells. The Rouget cell was renamed some years later due to its anatomical location abluminal to the endothelial cell (EC) and luminal to parenchymal cells. In the brain, pericytes are located in precapillary arterioles, capillaries and postcapillary venules. They deposit elements of the basal lamina and are totally surrounded by this vascular component. Pericytes are important cellular constituents of the blood–brain barrier (BBB) and actively communicate with other cells of the neurovascular unit such as ECs, astrocytes, and neurons. Pericytes are local regulatory cells that are important for the maintenance of homeostasis and hemostasis, and are a source of adult pluripotent stem cells. Further understanding of the role played by this intriguing cell may lead to novel targeted therapies for neurovascular diseases.

Key words

Angiogenesis Blood–brain barrier Capillaries Contractility DNA repair Endothelial cells Gap junction Homeostasis Migration Neurovascular unit Pericyte Stem cells Stress response Vascular injury