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Suppression and Regulation of Immune Responses

Volume 677 of the series Methods in Molecular Biology pp 397-417

Date:

Pregnancy: Tolerance and Suppression of Immune Responses

  • Anne Leber
  • , Maria Laura ZenclussenAffiliated withDepartment for Neurosurgery, Charite, Medical University of Berlin
  • , Ana TelesAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg
  • , Nadja BrachwitzAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg
  • , Pablo CasalisAffiliated withDepartment for Neurosurgery, Charite, Medical University of Berlin
  • , Tarek El-MouslehAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg
  • , Federico JensenAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg
  • , Katja WoidackiAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg
  • , Ana Claudia ZenclussenAffiliated withDivision of Reproductive Immunology, Department for Experimental Obstetrics and Gynaecology, University of Magdeburg

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Abstract

Presence of foreign tissue in a host’s body would immediately lead to a strong immune response directed to destroy the alloantigens present in fetus and placenta. However, during pregnancy, the semiallogeneic fetus is allowed to grow within the maternal uterus due to multiple mechanisms of immune tolerance, which are discussed in this chapter.

Key words

Pregnancy Tolerance Regulatory T cells Dendritic cells Heme oxygenase-1