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Protein Misfolding and Cellular Stress in Disease and Aging

Volume 648 of the series Methods in Molecular Biology pp 79-92

Date:

Autophagy in Disease

  • Dalibor MijaljicaAffiliated withDepartment of Biochemistry and Molecular Biology, Monash University
  • , Mark PrescottAffiliated withDepartment of Biochemistry and Molecular Biology, Monash University
  • , Rodney J. DevenishAffiliated withDepartment of Biochemistry and Molecular Biology and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University Email author 

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Abstract

Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment. It is therefore essential for the maintenance of cellular homeostasis and for an efficient response to cellular stresses. As such autophagy has been implicated either in the pathogenesis, or response to a wide variety of diseases, bacterial, and viral infections, and ageing.

Key words

Autophagy Degradation Disease Pathophysiology Stress