Alzheimer's Disease and Frontotemporal Dementia

Volume 670 of the series Methods in Molecular Biology pp 1-9


Contemporary Approaches to Alzheimer’s Disease and Frontotemporal Dementia

  • Erik D. RobersonAffiliated withDepartments of Neurology and Neurobiology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham

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Alzheimer’s disease and frontotemporal dementia are two of the most common neurodegenerative dementias. Here, we review the clinical presentation, genetic causes, typical neuropathology, and current treatments for these disorders. We then review molecules involved in their pathogenesis and protocols for working with these species and conclude with a discussion of experimental systems and outcome measures for studying these disorders.

Key words

Dementia Mild cognitive impairment Memory Personality change Disinhibition Aging Methods Protocols β-Amyloid Tau Apolipoprotein E Progranulin TDP-43