Methods in Molecular Biology Volume 629, 2010, pp 53-67

Progress in siRNA Delivery Using Multifunctional Nanoparticles

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Abstract

Nanoparticles made from synthetic polymers have been developed to deliver small interfering RNA (siRNA). For successful siRNA delivery, these nanoparticles need to efficiently encapsulate siRNA, actively target sites of interest, and release siRNA intracellularly. This chapter reviews recent progress using a multifunctional approach to design and engineer polymeric nanoparticles for siRNA delivery.