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Mouse Models for Drug Discovery

Volume 602 of the series Methods in Molecular Biology pp 55-77

Date:

Engineering the Mouse Genome to Model Human Disease for Drug Discovery

  • Frank KoentgenAffiliated withOzgene Pty. Ltd.
  • , Gabriele SuessAffiliated withOzgene Pty. Ltd.
  • , Dieter NafAffiliated withOzgene Pty. Ltd.

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Abstract

Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.

Key words

Transgenic mice gene targeting homologous recombination humanized mice knockout reporter gene