Protocol

Immunoinformatics

Volume 409 of the series Methods in Molecular Biology™ pp 19-42

IMGT®, the International ImmunoGeneTics Information System® for Immunoinformatics

Methods for Querying IMGT® Databases, Tools, and Web Resources in the Context of Immunoinformatics
  • Marie-Paule LefrancAffiliated withLaboratoired’ImmunoGénétique Moléculaire, Institut Universitaire de France

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Summary

IMGT ®, the international ImMunoGeneTics information system® (http://​imgt.​cines.​fr), was created in 1989 by the Laboratoire d’ImmunoGénétique Moléculaire (LIGM) (Université Montpellier II and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. IMGT ® is recognized as the international reference in immunogenetics and immunoinformatics. IMGT ® is a high quality integrated knowledge resource, specialized in (i) the immunoglobulin (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates; (ii) proteins that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF); and (iii) related proteins of the immune systems (RPI) of any species. IMGT ® provides a common access to standardized data from genome, proteome, genetics, and three-dimensional (3D) structures for the IG, TR, MHC, IgSF, MhcSF, and RPI. IMGT ® interactive on-line tools are provided for genome, sequence, and 3D structure analysis. IMGT ® Web resources comprise 8,000 HTML pages of synthesis and knowledge (IMGT Scientific chart, IMGT Repertoire, IMGT Education, etc.) and external links (IMGT Bloc-notes and IMGT other accesses).

Key Words

IMGT ontology immunoglobulin T cell receptor MHC IgSF MhcSF