Cancer Gene Profiling

Volume 576 of the series Methods in Molecular Biology pp 61-87


A Decade of Cancer Gene Profiling: From Molecular Portraits to Molecular Function

  • Henri SaraAffiliated withVTT Medical Biotechnology
  • , Olli KallioniemiAffiliated withVTT Medical Biotechnology
  • , Matthias NeesAffiliated withVTT Medical Biotechnology

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Cancer gene profiling has greatly profited from the progress in high-throughput technologies including microarray-, sequencing-, and bioinformatics-based methods. The flood of data generated during the last decade has provoked a panel of “-omics” fields that significantly changed our understanding of malignant diseases. However, while the terms “-omics” and “-ome” in principle refer to the completeness of a genetic approach, we are in fact far from a complete understanding of cancer progression. We may understand gene expression patterns better and successfully use gene signatures for outcome prediction and prognosis, but truly promising molecular targets still have to find their way into novel therapeutic concepts. In this chapter, we will show how more comprehensive strategies, integrating multiple layers of genetic information, might in the future provide a more profound functional understanding of cancer.

Key words

Microarray Expression CGH Comparative genomic hybridization Sequencing