Systems Biology

Volume 500 of the series Methods in Molecular Biology pp 1-11


Introduction: A Practical Guide to the Systems Approach in Biology

  • Ivan V. MalyAffiliated withDepartment of Computational Biology, University of Pittsburgh School of Medicine Email author 

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This essay provides an informal review of the modern systems-centric biological methodology for the practical researcher. The systems approach is defined, and a generic recipe for employing it in biomedical research is offered. General caveats are discussed that pertain to biological complexity, to explanation in molecular terms, and to bottom-up investigation. An outlook on the development of systems biology is also given.


Systems biology Methodology Mathematical modeling Complexity Physiology