Recombinant Proteins From Plants

Volume 483 of the series Methods in Molecular Biology™ pp 1-23

From Neanderthal to Nanobiotech: From Plant Potions to Pharming with Plant Factories

  • Christophe SourrouilleAffiliated withFaculté des Sciences, Université de Rouen
  • , Brian MarshallAffiliated
  • , David LiénardAffiliated withLI LIU, Department of Biological Chemistry, John Innes Centre
  • , Loïc FayeAffiliated withCNRS, Université de Rouen

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Plants were the main source for human drugs until the beginning of the nineteenth century when plantderived pharmaceuticals were partly supplanted by drugs produced by the industrial methods of chemical synthesis. During the last decades of the twentieth century, genetic engineering has offered an alternative to chemical synthesis, using bacteria, yeasts and animal cells as factories for the production of therapeutic proteins. After a temporary decrease in interest, plants are rapidly moving back into human pharmacopoeia, with the recent development of plant-based recombinant protein production systems offering a safe and extremely cost-effective alternative to microbial and mammalian cell cultures. In this short review, we will illustrate that current improvements in plant expression systems are making them suitable as alternative factories for the production of either simple or highly complex therapeutic proteins.

Key words

Glycosylation Molecular farming Plant-made pharmaceutical Recombinant protein Transgenic plant Therapeutic protein