The Chronological Life Span of Saccharomyces cerevisiae
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The chronological life span of yeast, which is measured as the survival time of populations of nondividing cells, has been used successfully for the identification of key pathways responsible for the regulation of aging. These pathways have remarkable similarities with those that regulate the life span in higher eukaryotes, suggesting that longevity depends on the activity of genes and signaling pathways that share a common evolutionary origin Thus, the unicellular Saccharomyces cerevisiae is a simple model system that can provide significant insights into the human genetics and molecular biology of aging. Here, we describe the standard procedures to measure the chronological life span, including both the normal and calorie restriction paradigms.
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- The Chronological Life Span of Saccharomyces cerevisiae
- Book Title
- Biological Aging
- Book Subtitle
- Methods and Protocols
- pp 89-95
- Print ISBN
- Online ISBN
- Series Title
- Methods in Molecular Biology™
- Series Volume
- Series ISSN
- Humana Press
- Copyright Holder
- Humana Press
- Additional Links
- Chronological aging
- calorie restriction
- Industry Sectors
- Editor Affiliations
- 1. Department of Biology, University of Alabama at Birmingham
- Author Affiliations
- 2. Andrus Gerontology Center, Division of Biogerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA
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