The Mycobacterium tuberculosis Phagosome
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Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms, inside macrophages. Recent work has identified host GTPases involved in the block of normal phagolysosome biogenesis during mycobacterial infection and has provided a set of methods, in particular efficient macrophage transfection, which will prove essential in examining the role of host effectors in this process.
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- The Mycobacterium tuberculosis Phagosome
- Book Title
- Autophagosome and Phagosome
- pp 439-449
- Print ISBN
- Online ISBN
- Series Title
- Methods in Molecular Biology™
- Series Volume
- Series ISSN
- Humana Press
- Copyright Holder
- Humana Press
- Additional Links
- M. tuberculosis
- Rab conversion
- Industry Sectors
- Vojo Deretic (2)
- Editor Affiliations
- 2. Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center
- Author Affiliations
- 3. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM
- 4. Health Sciences Center, Department Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
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