Protocol

Cardiac Gene Expression

Volume 366 of the series Methods in Molecular Biology pp 229-251

Comparative Genomics

A Tool to Functionally Annotate Human DNA
  • Jan-Fang ChengAffiliated withGenomics Division, Lawrence Berkeley National LaboratoryJoint Genome Institute, U.S. Department of Energy
  • , James R. PriestAffiliated withGenomics Division, Lawrence Berkeley National LaboratoryJoint Genome Institute, U.S. Department of Energy
  • , Len A. PennacchioAffiliated withGenomics Division, Lawrence Berkeley National LaboratoryJoint Genome Institute, U.S. Department of Energy

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The availability of an increasing number of vertebrate genomes has enabled comparative methods to infer functional sequences based on evolutionary constraint. Although this has proved powerful for gene identification, significant progress has also been made in uncovering gene regulatory sequences such as distant acting transcriptional enhancers. These pursuits have led to the development of a variety of valuable databases and resources that should serve as a routine toolbox for biological discovery.

Key Words

Comparative genomics gene regulation enhancer transcription databases